Dr. Vasileios F. Zymperdikas is a Military Dentist and Postgraduate Student in the Department of Orthodontics of the Aristotle University of Thessaloniki. He received his Dental Degree from the School of Dentistry of the Aristotle University of Thessaloniki in 2011 and he graduated from the Military School of Combat Support Officers in 2012.
During 2012-2013, he worked at the Dental Department and at the Oral and Maxillofacial Surgical Clinic of the 401 Military Hospital of Athens. Subsequently, he served at the 71st Airmobile Brigade in Nea Santa, Greece as a dental officer and a medic instructor. At the same time, he was commissioned as a NATO officer, responsible for matters of transnational organization of military medical support, logistics and sanitation, where he was rewarded twice for his accomplishments. Additionally, he has participated in national and international congresses.
He has also co-authored five scientific articles and two orthodontic book chapters. From April 2017, he serves as the Greek Ambassador for the European Postgraduate Students Orthodontic Society (EPSOS).
INVITED LECTURE: Bisphosphonates in orthodontics: myths and facts.
Vasileios F. Zymperdikas, Moschos A. Papadopoulos
BACKGROUND: Bisphosphonates are a class of drugs that through the inhibition of osteoclastic activity reduce bone turnover. Consequently, these drugs are reported to interfere with orthodontic movement, since the latter depends on bone metabolism.
OBJECTIVE: Aim of this review was to summarize existing evidence regarding the effectiveness of orthodontic treatment in patients receiving bisphosphonates.
MATERIALS AND METHODS: Unrestricted electronic search of 18 databases was performed up to August 2015. Studies reporting on orthodontic patients under bisphosphonate treatment due to bone-related diseases were included. Data regarding the patient characteristics, the pharmaceutical protocol and the orthodontic procedures were extracted. The primary outcomes were classified as clinical or radiographic. The ROBINS-I tool was implemented for risk of bias judgement of non-randomized studies, while a modified checklist from the one proposed by Agbabiaka et al was used for quality analyses of case reports.
RESULTS: Six studies (5 case reports and 1 retrospective cohort study) were included in the present review, reporting on 28 patients. Orthodontic treatment was associated with longer duration, slower rates of tooth movement and compromised results. Additionally, a controversy exists regarding the observed root resorption as well as the changes in PDL space and the alveolar bone. Moreover, the cohort study was judged with “critical” risk of bias, while the overall case report quality was considered as “lower medium”.
CONCLUSIONS: According to current evidence, orthodontic treatment in bisphosphonate patients appears to be associated with compromised outcomes and longer duration owing to impaired osteoclast function and subsequent reduced bone turnover.